Alkyl ether of isourea.



:'.MAx ENG LM ANN nnnrmmmcr MERKEL, or LBERF LD, GERMANY, A SSIGNORS {ToFARBENFABmKE .vo'RM. FRIED BAYERK: co., or ELBERFELD, ERMAN a CORPORATION OF GERMANY.

- ALKYL ETHER or. isounna no Drawing.

"To all whom it may concern:

Be It known that we, MAX ENGELMANN' 'andBEuEnIor lVlniumL, doctors of philosophy, chemists, citizens of the German Emp1re, resi'ding'at Elberfeld, Germany, have invented new and useful Improvements in -A1kyl Ethers of Isoiirea,of which thefollowing is a specification. j

Our invention concerns the production of the hitherto unknown ether-s. of -diethyl-' 'bromo-acetylisou-rea, which have proved to bromodiethylacetylurea .,thus obtained is crystallized from alcohol. niethylether other derivatives 0. g. isoureaethylether or isoureabenzylether can also be used; 1

i be valuable sedatives an-average dose being from 7} to gra1n.- The process for their 1 production conslstsin treating the ethers of,

- isourea' of the formulaf I (Rial s i fiv -i 9- l' y orearned)- or v their salts with diethylbromo'acetyl haloidg in the presence of alkaline agents. The new products having most pro I i C2115 I Y C-Br ozm/ v o-nnz on are crystalline compound-s b'eing' converted. yt'reat-ing' them With-acids into the b1"oIIio-- i diethyl-acetylurea: 3 I i i ;-I1'i order to illustrate; the new process more fullyn'the following example is" given, theiparts ibeing by "weight zparts of the i-me thyleth er of isourea hydrochlorid;

separates It after Sfiecifiation of Letters Patent. Applicationfiled Angust '9, 1'911; Serial. No.- $43,197.

bably the formula Paten tedJune 11, 1912;

. drying recrystallized froln- -ligroin. This ether forms colorless Crystalsinelting at 72 C. It is rather slightly. soluble in cold 7 water but'ieasilyisoluble in alcohol, ether, acetone. and acids. -By. heating the ether with an acid 6. g. HCI or itssalts e. g. the

'hydrochloridit-is converted into the brolno- "diethyl'acetylurea, For. Qthis purpose parts [,of the etherare' heated with 150 parts of a strong hydrocl lloric acid on the water bath ehloromethyl .being'disengaged. The

Instead of the -W'e-claim:

1. The herein described ethers otdiethylbeing crystalline powders being converted into bromodiethylacetylureabytreatment with a hot acidy-and 'being 'valuable sedatives,substantially as described. iv v :2. The herein described'methylether of d-i-. ethylhromoacetylisourea having most probably the-formula:

being acrystall'ine powder melting-at 70 C,

difiicultly soluble-in cold Water, easilysolu 1 .ble in alcohol, ether, acetone" and inacids; and beinga valuable sedative, substantially as described. 4

-'--In" te stin10n y whereof we have hereunto set our'hands 1n the"p'rese'noe of two subscribing witnesses MAX ENGELMANN; he BENEDICT *MERKEL; a 8.

Witne s ss CH ALBERT. F. Nurmi.-

broinoacetylisoureahaving inost pmbablytl'1e formula: 

